White Paper - Deutenomics
1) Deuterium and hydrogen distribution with threshold ratios within molecules, cells, tissues, body fluids, etc... determine health and (chronic) disease states! https://doi.org/10.1073/pnas.2412390121
2) Deuterium enters the body through nutrients and its content depends largely on the ratio of carbohydrates, proteins, and fats they contain, as well as the location and conditions where plants and animal products originate from! https://doi.org/10.1007/s11306-021-01855-7
3) Dietary deuterium load from grass-fed animal products is significantly lower than that expected from animals fed with grains and/or artificial supplements!
4) Deuterons above biological thresholds compromise mitochondrial health and thus our cells' ability to produce energy for healthy life during the continuous turning over of structural molecules to maintain it! https://doi.org/10.1016/j.mehy.2015.11.016
Direct glucose oxidation in the pentose cycle, followed by glycolysis and single carbon cycles are responsible for Warburg metabolisms to compensate for defective mitochondrial fatty acid oxidation and compromised deuterium depleting metabolic water exchange reactions in tumor cells. The following original studies laid the foundation for deutenomics to control cell transformation via the regulation of nutritional deuterium exposure:
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1) Nonoxidative pentose phosphate pathways and their direct role in ribose synthesis in tumors: is cancer a disease of cellular glucose metabolism? https://doi.org/10.1016/S0306-9877(98)90178-5
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2) Metabolic control analysis in drug discovery and disease. https://doi.org/10.1038/nbt0302-243​​
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3) Imatinib and chronic-phase leukemias. https://www.nejm.org/doi/full/10.1056/NEJM200207043470116
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4) Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle. https://doi.org/10.1016/j.mehy.2015.11.016
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5) What to eat or what not to eat—that is still the question. https://doi.org/10.1093/neuonc/now284